Monograph Details
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Cardiovascular System
> Hypertension
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VASERETIC 5-12.5 |
| Manufacturer |
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Biovail Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor + diuretic. |
| Generic Name |
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Enalapril maleate 5mg, hydrochlorothiazide 12.5mg; tabs. |
| Also |
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• VASERETIC 10-25
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Switching from monotherapy with either component: start with Vaseretic 5-12.5 or 10-25 once daily, then adjust; max 20mg enalapril/day. Allow 2–3 weeks for titration of HCTZ component. Or, substitute for individually titrated components. |
| Elderly |
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Reduce dose. |
| Contraindications |
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Anuria. Sulfonamide allergy. History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Severe renal impairment: not recommended. Renal or hepatic dysfunction. Salt/volume depletion. CHF. Ischemic disease. Renal artery stenosis. Dialysis (esp. high-flux membrane). Surgery. Diabetes. Gout. Asthma. Postsympathectomy. Monitor WBCs in renal or collagen vascular disease. Discontinue immediately if angioedema or laryngeal edema occurs. Monitor electrolytes and renal function. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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May cause hyperkalemia with K+-sparing diuretics or supplements. Hypokalemia with corticosteroids, ACTH, amphotericin B. NSAIDs may cause renal failure. May increase digitalis, lithium, diazoxide toxicity. Alcohol, CNS depressants may increase orthostatic hypotension. Adjust antidiabetic, antigout medications. Potentiates nondepolarizing muscle relaxants. Antagonizes norepinephrine. Antagonized by NSAIDs. May interfere with parathyroid tests. |
| Adverse Reactions |
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Cough, dizziness, headache, fatigue, myalgia, nausea, asthenia, orthostatic hypotension, diarrhea, angioedema, fluid or electrolyte imbalance, impotence, hyperuricemia, renal impairment, arrhythmias. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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