Monograph Details
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Cardiovascular System
> Hypertension
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UNIVASC |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Moexipril HCl 7.5mg, 15mg; scored tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Take 1 hr before meals. Initially and if not on diuretics: 7.5mg once daily; usual range 15–30mg/day in 1–2 divided doses; max 30mg/day. If on diuretic: suspend diuretic for 2–3 days before starting therapy; resume diuretic if blood pressure not controlled by moexipril alone. If diuretic cannot be discontinued: initially 3.75mg once daily. CrCl <40mL/min per 1.73m2: initially 3.75mg once daily; max 15mg/day. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal impairment. Hypovolemia. CHF. Renal artery or aortic stenosis. Cerebrovascular or ischemic heart disease. Diabetes. Dialysis (esp. high-flux membrane). Surgery. Monitor WBCs in collagen vascular disease. Discontinue if angioedema, laryngeal edema, jaundice or markedly elevated liver enzymes occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Excessive hypotension with diuretics. Monitor lithium. |
| Adverse Reactions |
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Cough, dizziness, diarrhea, flu syndrome, fatigue, pharyngitis, flushing, angioedema (eg, intestinal), rash, myalgia, hyperkalemia, hyponatremia. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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