Monograph Details
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Cardiovascular System
> Hypertension
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UNIRETIC 15mg/12.5mg |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Moexipril HCl 15mg, hydrochlorothiazide 12.5mg; scored tabs. |
| Also |
• UNIRETIC 15mg/25mg
• UNIRETIC 7.5mg/12.5mg
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Not for initial therapy. Take 1 hour before a meal. Switching from monotherapy with either component: 1 tab once daily; adjust at 2–3 week intervals; usual max 30mg/50mg per day. Or, substitute for individually-titrated components. |
| Contraindications |
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History of ACEI-associated angioedema. Anuria. Sulfonamide allergy. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal impairment (CrCl ≤40mL/min): not recommended. Discontinue if angioedema, laryngeal edema, jaundice, or marked elevation of hepatic enzymes occurs. Renal or hepatic dysfunction. Salt/volume depletion. CHF. Ischemic heart disease. Aortic or renal artery stenosis. Cerebrovascular disease. Dialysis (esp. high-flux membrane). Surgery. Diabetes. Gout. Asthma. Postsympathectomy. Monitor WBC counts in renal or collagen vascular disease. SLE. Monitor electrolytes and renal function. Elderly. Pregnancy (Cat.C in 1st trimester), nursing mothers: not recommended. |
| Interactions |
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May cause hyperkalemia with K+ sparing diuretics, K+ supplements, or K+ containing salt substitutes. Hypokalemia with corticosteroids, ACTH, amphotericin B. May increase lithium, digitalis, diazoxide toxicity. Alcohol, CNS depressants may increase orthostatic hypotension. Adjust antidiabetic, antigout medications. Potentiates nondepolarizing muscle relaxants. Antagonizes norepinephrine. Antagonized by, and increased risk of renal failure with, NSAIDs. May interfere with parathyroid tests. |
| Adverse Reactions |
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Cough, dizziness, fatigue, headache, hyperuricemia, electrolyte disturbances, hyperglycemia, rash, GI upset, angioedema (eg, intestinal), orthostatic hypotension, neutropenia. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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