Monograph Details
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Cardiovascular System
> Hypertension
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TRANDATE |
| Manufacturer |
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Prometheus Labs, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Noncardioselective β-blocker/α1-blocker. |
| Generic Name |
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Labetalol HCl 100mg, 200mg, 300mg; scored tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Initially 100mg twice a day. Titrate at 2–3 day intervals in increments of 100mg twice daily. Usual maintenance: 200–400mg twice daily; max 2.4g/day. |
| Elderly |
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Usual maintenance: 100–200mg twice daily. |
| Contraindications |
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Asthma. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock. Severe bradycardia, other conditions associated with prolonged or severe hypotension. |
| Precautions |
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Ischemic heart disease or failure. Monitor hepatic function; discontinue at first sign of liver injury. COPD. Pheochromocytoma. Diabetes. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Caution with verapamil. Potentiates hypotension with nitroglycerin. May block epinephrine, β-agonist bronchodilators. Adjust antidiabetic medication. Potentiated by cimetidine. Tremor with tricyclic antidepressants. Halothane. |
| Adverse Reactions |
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Dizziness, GI upset, fatigue, nasal stuffiness, ejaculation failure, headache, dyspnea, vertigo, rash, orthostatic hypotension, edema, heart failure, bronchospasm, jaundice. |
| How Supplied |
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Tabs—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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