Monograph Details
|
|
Cardiovascular System
> Hypertension
|
|
TENORMIN |
| Manufacturer |
|
AstraZeneca Pharmaceuticals |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Cardioselective β-blocker. |
| Generic Name |
|
Atenolol 25mg, 50mg, 100mg; tabs. |
| Indications |
|
Hypertension. |
| Children |
|
Not recommended. |
| Adults |
|
Initially 50mg daily. May increase after 1–2 weeks to 100mg once daily; max 100mg/day. Elderly: Initially 25-50mg daily; monitor trough BP. CrCl 15–35mL/minute: max 50mg/day; CrCl <15mL/minute: max 25mg/day; monitor trough BP. Coincide a dose for the end of hemodialysis. |
| Contraindications |
|
Sinus bradycardia. 2nd- or 3rd-degree heart block. Overt heart failure. Cardiogenic shock. |
| Precautions |
|
Bronchospastic disease. Renal dysfunction. Diabetes. Hyperthyroidism. Pheochromocytoma. Surgery. Avoid abrupt cessation. Peripheral circulatory disorders. Ischemic heart disease or failure. Pregnancy (Cat.D): not recommended. Nursing mothers. |
| Interactions |
|
Additive effect with catecholamine-depleting drugs, prazosin, digoxin. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Increased rebound hypertension with clonidine withdrawal. May block epinephrine. |
| Adverse Reactions |
|
Heart failure, bronchospasm, bradycardia, angina, MI, heart block, dizziness, fatigue, GI upset, depression, orthostatic hypotension, cold extremities. |
| How Supplied |
Tabs 25mg, 100mg—100
50mg—100, 1000 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
