Monograph Details
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Cardiovascular System
> Hypertension
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TENORETIC 50 |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cardioselective β-blocker + diuretic. |
| Generic Name |
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Atenolol 50mg, chlorthalidone 25mg; scored tabs. |
| Also |
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• TENORETIC 100
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Switching from monotherapy: initially one Tenoretic 50 tab daily; may increase to one Tenoretic 100 tab daily. CrCl 15–35mL/minute: max 50mg atenolol/day. CrCl <15mL/minute: max 50mg atenolol every other day. |
| Contraindications |
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Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. Anuria. Sulfonamide allergy. Pregnancy (Cat.D). |
| Precautions |
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Heart failure. Bronchospastic disease. Renal or hepatic dysfunction. SLE. Gout. Diabetes. Asthma. Hyperthyroidism. Hypokalemia. Surgery. Postsympathectomy. Peripheral circulatory disorders. Avoid abrupt cessation. Monitor electrolytes. Excessive diuresis. Potassium supplementation may be needed. Nursing mothers: not recommended. |
| Interactions |
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May potentiate hypotension with prazosin, alcohol, catecholamine-depleting drugs, CNS depressants. May increase toxicity of diazoxide, digitalis, lithium. Conduction abnormalities, bradycardia, heart block with calcium channel blockers (esp. verapamil, diltiazem). Adjust antidiabetic medications. Increased rebound hypertension with clonidine withdrawal. May block epinephrine. May increase responsiveness to tubocurarine. ACTH, steroids, amphotericin B increase risk of hypokalemia. |
| Adverse Reactions |
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Heart failure, bronchospasm, bradycardia, heart block, dizziness, fatigue, fluid or electrolyte imbalance, hyperuricemia, orthostatic hypotension, GI upset, cold extremities. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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