Monograph Details
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Cardiovascular System
> Hypertension
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TENEX |
| Manufacturer |
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PDL BioPharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Central α2-agonist. |
| Generic Name |
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Guanfacine (as HCl) 1mg, 2mg; tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Initially 1mg/day at bedtime. May increase to 2mg/day at bedtime; usual max 3mg/day. |
| Contraindications |
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Hypertension due to toxemia of pregnancy. |
| Precautions |
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Severe coronary insufficiency. Recent MI. Cerebrovascular disease. Chronic renal or hepatic failure. Avoid abrupt cessation. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Additive sedation with alcohol, other CNS depressants. Caution with microsomal enzyme inducing drugs (e.g., barbiturates, phenytoin) in renal impairment. |
| Adverse Reactions |
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Dry mouth, somnolence, dizziness, headache, impotence, asthenia, constipation, fatigue. |
| How Supplied |
Tabs 1mg—100, 500
Tabs 2mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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