Monograph Details
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Cardiovascular System
> Hypertension
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TARKA 4/240 |
| Manufacturer |
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Abbott Laboratories |
| Legal Classification |
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Rx
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| Generic Name |
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Trandolapril 4mg, verapamil HCl 240mg (ext-rel); tabs. |
| Also |
• TARKA 1/240
• TARKA 2/180
• TARKA 2/240
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| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Not for initial therapy. Titrate individual components. Take with food. ≥18yrs: 1 tab daily. |
| Contraindications |
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History of ACEI-associated angioedema. Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Discontinue if laryngeal edema, angioedema, or jaundice occurs. Hepatic or renal dysfunction. Salt/volume depletion. CHF. Renal artery or aortic stenosis. Cerebrovascular or ischemic heart disease. Monitor liver function. Monitor for neutropenia in collagen vascular and/or renal disease and for hyperkalemia in diabetics. Dialysis (esp. high-flux membrane). Surgery. Black patients may have higher risk of angioedema than non-black patients. Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hypertrophic cardiomyopathy. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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For trandolapril: Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+-sparing diuretics, salt substitutes. May increase lithium levels. For verapamil: Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. |
| Adverse Reactions |
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Cough, AV block, constipation, dizziness, elevated liver enzymes, fatigue, chest pain, bradycardia, joint pain, GI upset, bronchitis, dyspnea, pain in extremities, paralytic ileus. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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