Monograph Details

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Cardiovascular System > Hypertension

PRINZIDE 10-12.5

Manufacturer

Merck & Co., Inc.

Legal Classification

Pharmacological Class

ACE inhibitor + diuretic.

Generic Name

Lisinopril 10mg, hydrochlorothiazide 12.5mg; tabs.

Also

• PRINZIDE 20-12.5
• PRINZIDE 20-25

Indications

Hypertension.

Children

Not recommended.

Adults

Not for initial therapy. Usual maintenance: 1–2 tabs of 20-12.5 or 20-25 once daily, or 1 tab of 10-12.5 once daily.

Contraindications

CrCl <30mL/min or serum creatinine >3mg/dL. History of ACEI-associated or other angioedema. Anuria. Sulfonamide hypersensitivity. Pregnancy (Cat.D in 2^nd and 3^rd trimesters).

Precautions

CHF. Coronary or cerebrovascular ischemia. Arrhythmias. Salt/volume depletion. Postsympathectomy. Renal or hepatic impairment. Dialysis (esp. high-flux membrane). Diabetes. Gout. Asthma. Renal artery stenosis. Surgery. Monitor electrolytes, renal function. Monitor WBCs in renal and collagen vascular disease. Discontinue if neutropenia, angioedema or laryngeal edema occurs (SC epinephrine should be available). Pregnancy (Cat.C in 1^st trimester). Nursing mothers: not recommended.

Interactions

Potentiated by antihypertensives. Potentiates tubocurarine. May antagonize sulfonylureas, oral anticoagulants, uricosurics. May be antagonized by NSAIDs, sympathomimetics. May increase digitalis, lithium, insulin, diazoxide toxicity. Hyperkalemia with K⁺-sparing diuretics and supplements. Hypokalemia with ACTH, corticosteroids. Orthostatic hypotension may be increased by alcohol, CNS depressants. May interfere with parathyroid, urinary acetone tests.

Adverse Reactions

Dizziness, headache, cough, fatigue, orthostatic hypotension, GI disturbances, upper respiratory infection, muscle cramps, asthenia, paresthesia, rash, impotence, electrolyte disturbances (hypokalemia, hyperkalemia, hyponatremia), hyperuricemia.

How Supplied

Tabs—100

Additional Resources

• Related Prescribing Note