Monograph Details
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Cardiovascular System
> Hypertension
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PLENDIL |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (dihydropyridine). |
| Generic Name |
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Felodipine 2.5mg, 5mg, 10mg; ext rel tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Take without food or with a light meal. Do not crush or chew. Initially 5mg once daily. Range 2.5–10mg once daily. Adjust at 2 week intervals; max 10mg daily. Elderly or hepatic dysfunction: initially 2.5mg once daily. |
| Precautions |
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Heart failure. Hepatic impairment. Maintain good dental hygiene. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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May increase metoprolol, tacrolimus levels. Potentiated by cimetidine. Increased bioavailability with grapefruit juice. Levels decreased with long-term anticonvulsants (e.g., carbamazepine, phenytoin, phenobarbital), consider alternate antihypertensive therapy. |
| Adverse Reactions |
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Peripheral edema, headache, flushing, dizziness, respiratory symptoms, weakness, cough, GI upset, gynecomastia; hypotension, tachycardia, syncope, MI, angina, gingival hyperplasia (rare). |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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