Monograph Details
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Cardiovascular System
> Hypertension
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Nicardipine |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (dihydropyridine). |
| Generic Name |
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Nicardipine HCl 20mg, 30mg; caps. |
| Also |
• CARDENE IV
• CARDENE SR
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| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg daily. Severe hepatic impairment: initially 20mg twice daily. |
| Contraindications |
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Advanced aortic stenosis. |
| Precautions |
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Cardiac failure. Angina. Acute cerebral infarction or hemorrhage. Hepatic or renal impairment. Pheochromocytoma. For regular capsules: measure blood pressure (BP) 1–2 hrs and 8 hrs after dosing. For SR: measure BP at 2–4 hrs and at end of dosing interval. For IV: monitor BP before and during infusion; avoid rapid or excessive reductions; switch to oral form when possible. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiated by cimetidine. Increases serum levels of cyclosporine, possibly digoxin. |
| Adverse Reactions |
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Increased angina, flushing (caps, SR), headache, pedal edema, asthenia, dizziness, somnolence (caps), tachycardia, GI upset, sweating; ECG abnormalities, orthostatic hypotension, ventricular extrasystoles, local reactions (inj). |
| How Supplied |
Caps 20mg, 30mg—contact supplier
SR—60
IV (10mL amps)—10 |
| Additional Resources |
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• Related Prescribing Note |
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