Monograph Details
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Cardiovascular System
> Hypertension
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MICROZIDE |
| Manufacturer |
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Watson Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Diuretic. |
| Generic Name |
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Hydrochlorothiazide 12.5mg; caps. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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12.5mg once daily; usual max 50mg/day. |
| Contraindications |
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Anuria. Sulfonamide allergy. |
| Precautions |
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Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Parathyroid disease. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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May cause digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests. Additive effects with other antihypertensives. |
| Adverse Reactions |
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Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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