Monograph Details
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Cardiovascular System
> Hypertension
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MAVIK |
| Manufacturer |
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Abbott Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Trandolapril 1mg+, 2mg, 4mg; tabs; +scored. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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If not on diuretic: initially 1mg once daily in non-black patients; 2mg in black patients. If on diuretic: suspend diuretic for 2–3 days before starting therapy; resume diuretic if BP not controlled with trandolapril alone. If diuretic cannot be discontinued (supervise closely until stabilized), or in renal impairment (CrCl <30mL/min) or hepatic cirrhosis: initially 0.5mg once daily. For all: adjust at 1-week intervals; usual range 2–4mg once daily; usual max 8mg/day; may give in 2 divided doses. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal impairment. Salt/volume depletion. Renal artery stenosis. Monitor for neutropenia in collagen vascular and/or renal disease. Monitor for hyperkalemia in diabetics. Dialysis (esp. high-flux membrane). Surgery. Discontinue if laryngeal edema, angioedema, or jaundice occurs. Avoid hypotension in CHF, aortic stenosis, ischemic heart disease, or cerebrovascular disease. Black patients may have higher risk of angioedema than non-black patients. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+-sparing diuretics, or salt substitutes. May increase lithium levels. |
| Adverse Reactions |
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Cough, dizziness, diarrhea. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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