Monograph Details
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Cardiovascular System
> Hypertension
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LOTENSIN HCT 20/12.5 |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Generic Name |
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Benazepril (as HCl) 20mg, hydrochlorothiazide 12.5mg; scored tabs. |
| Also |
• LOTENSIN HCT 10/12.5
• LOTENSIN HCT 20/25
• LOTENSIN HCT 5/6.25
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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To switch from benazepril monotherapy: see literature. Or, titrate individual components. |
| Contraindications |
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History of ACEI-associated or other angioedema. Anuria. Sulfonamide allergy. Renal dysfunction. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Discontinue if angioedema or laryngeal edema occurs. Salt/volume depletion. Renal or hepatic impairment. Electrolyte abnormalities (esp. hyper- or hypokalemia). Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Postsympathectomy. SLE. Diabetes. Gout. Maintain adequate fluid intake. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Potassium or potassium-sparing diuretics may cause hyperkalemia. May increase lithium levels. Potentiated by antihypertensives. Potentiates tubocurarine. May be antagonized by NSAIDs. Antagonizes norepinephrine. Anion exchange resins. Orthostatic hypotension potentiated by alcohol, CNS depressants. May interfere with parathyroid test. Hypokalemia with ACTH, corticosteroids. |
| Adverse Reactions |
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Dizziness, fatigue, orthostatic hypotension, headache, cough, GI disturbances, impotence, somnolence, electrolyte imbalance, rash, Stevens-Johnson syndrome. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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