Monograph Details
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Cardiovascular System
> Hypertension
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LOTENSIN |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Benazepril (as HCl) 5mg, 10mg, 20mg, 40mg; tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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If not on diuretic: initially 10mg daily. Usual maintenance: 20–40mg daily in 1 or 2 divided doses; usual max 80mg/day. If on diuretic: discontinue diuretic, if possible, 2–3 days before starting; resume diuretic if pressure not controlled with benazepril alone. If diuretic cannot be discontinued: initially 5mg daily. Creatinine clearance <30mL/min/1.73m2: initially 5mg daily; max 40mg/day. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Salt/volume depletion. Renal or hepatic impairment. Monitor WBCs in renal or collagen vascular disease. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Monitor for hyperkalemia in diabetics. Surgery. Discontinue if angioedema or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers. |
| Interactions |
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Potassium or potassium-sparing diuretics may cause hyperkalemia. May increase lithium levels. Potentiated by diuretics. |
| Adverse Reactions |
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Headache, dizziness, fatigue, GI upset, cough, angioedema, orthostatic hypotension, hyperkalemia. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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