Monograph Details
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Cardiovascular System
> Hypertension
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LOPRESSOR HCT 50/25 |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cardioselective β-blocker + diuretic. |
| Generic Name |
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Metoprolol tartrate 50mg, hydrochlorothiazide 25mg; scored tabs. |
| Also |
• LOPRESSOR HCT 100/25
• LOPRESSOR HCT 100/50
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Titrate individual components. |
| Contraindications |
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Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. Anuria. Sulfonamide allergy. |
| Precautions |
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CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Monitor electrolytes. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiated by alcohol, CNS depressants, other antihypertensives. Bradycardia with catecholamine-depleting drugs. Metoprolol potentiated by felodipine. Increased toxicity of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Antagonized by NSAIDs, barbiturates, rifampin. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. Adjust antidiabetic medication. May antagonize epinephrine. May interfere with parathyroid, glaucoma screening tests. |
| Adverse Reactions |
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Fatigue, bronchospasm, dizziness, drowsiness, headache, fluid or electrolyte imbalance, bradycardia, depression, dyspnea, GI upset, blurred vision, tinnitus, earache, impotence, myalgia, cold extremities, CHF, heart block. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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