Monograph Details
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Cardiovascular System
> Hypertension
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ISOPTIN SR |
| Manufacturer |
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FSC Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (diphenylalkylamine). |
| Generic Name |
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Verapamil HCl 120mg, 180mg+, 240mg+; sust-rel tabs; +scored. |
| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Take with food. Initially 120–180mg in the AM. May increase to 240mg in the AM; then 180mg every 12 hrs or 240mg in the AM and 120mg in the evening; then 240mg every 12 hrs. |
| Contraindications |
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Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. |
| Precautions |
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Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. |
| Adverse Reactions |
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Constipation, dizziness, nausea, hypotension, headache, edema, CHF, fatigue, dyspnea, bradycardia, AV block, rash, flushing, elevated hepatic enzymes, paralytic ileus. |
| How Supplied |
120mg, 180mg—100
240mg—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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