Monograph Details
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Cardiovascular System
> Hypertension
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INDERIDE 80/25 |
| Manufacturer |
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Akrimax Pharmaceuticals |
| Legal Classification |
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Rx
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| Generic Name |
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Propranolol HCl 80mg, hydrochlorothiazide 25mg; scored tabs. |
| Also |
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• INDERIDE 40/25
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Titrate individual components. |
| Contraindications |
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Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy. |
| Precautions |
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Overt heart failure. Ischemic heart disease. Wolff-Parkinson-White syndrome. Bronchospasm, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Potentiates antipyrine, lidocaine, nondepolarizing muscle relaxants, theophylline. Adjust antidiabetic medication. May increase cardiac effects of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid, glaucoma screening tests. May block epinephrine. |
| Adverse Reactions |
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Heart failure, bronchospasm, bradycardia, heart block, fatigue, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, orthostatic hypotension, dizziness, GI upset, depression, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), photosensitivity, pharyngitis, agranulocytosis. |
| How Supplied |
Tabs 40/25—100, 1000
80/25—100 |
| Additional Resources |
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• Related Prescribing Note |
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