Monograph Details
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Cardiovascular System
> Hypertension
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INDERAL |
| Manufacturer |
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Akrimax Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Noncardioselective β-blocker. |
| Generic Name |
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Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs. |
| Also |
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• INDERAL LA
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| Indications |
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Hypertension. Adjunct in pheochromocytoma. |
| Children |
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Initially 1mg/kg daily. Usual range: 2–4mg/kg per day in 2 divided doses; max 16mg/kg per day. |
| Adults |
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Initially 40mg twice a day. Usual maintenance: 120–240mg daily; max 640mg daily. Pheochromocytoma: 60mg daily in divided doses for 3 days pre-op or 30mg daily in inoperable cases. |
| Contraindications |
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Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock. |
| Precautions |
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CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests. |
| Adverse Reactions |
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Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis. |
| How Supplied |
Tabs 60mg—100
10mg, 20mg, 40mg, 80mg—100, 5000
LA—100 |
| Additional Resources |
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• Related Prescribing Note |
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