Monograph Details
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Cardiovascular System
> Hypertension
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Hydralazine Tablets |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Generic Name |
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Hydralazine HCl 10mg, 25mg, 50mg, 100mg. |
| Also |
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• Hydralazine Injection
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| Indications |
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Hypertension. |
| Children |
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Initially 0.75mg/kg per day in 4 divided doses, increase gradually over 3–4 weeks; max 7.5mg/kg or 200mg daily. |
| Adults |
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Initially 10mg 4 times daily for 2–4 days, then increase to 25mg 4 times daily for rest of 1st week, then to 50mg 4 times daily; max 300mg/day. |
| Contraindications |
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Coronary artery disease. Mitral valve disease. |
| Precautions |
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Suspected coronary artery disease. Cerebrovascular accidents. Aortic aneurysm. Increased intracranial pressure. Renal disease. Treat paresthesias and/or numbness with pyridoxine. Discontinue if blood dyscrasias occur. Obtain CBC and ANA titer periodically; consider discontinuing if SLE occurs. Surgery. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Caution with MAOIs. Profound hypotension with potent parenteral antihypertensives (eg, diazoxide). Antagonized by NSAIDs. May block epinephrine. |
| Adverse Reactions |
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Headache, anorexia, GI disturbances, palpitations, edema, flushing, nasal congestion, lacrimation, rash, tachycardia, angina, orthostatic hypotension, blood dyscrasias, peripheral neuritis, SLE. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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