Monograph Details
|
|
Cardiovascular System
> Hypertension
|
|
Hydralazine Injection |
| Manufacturer |
|
Various generic manufacturers |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Vasodilator. |
| Generic Name |
|
Hydralazine (as HCl) 20mg/mL; IM or IV inj; contains parabens. |
| Also |
|
• Hydralazine Tablets
|
| Indications |
|
Severe essential hypertension when oral therapy not feasible or there is an urgent need to lower blood pressure. |
| Children |
|
Not recommended; doses of 1.7–3.5mg/kg per day in 4–6 divided doses have been used. |
| Adults |
|
Monitor BP closely. 20–40mg; repeat as needed. Advanced renal damage: reduce dose. |
| Contraindications |
|
Coronary artery disease. Mitral valve disease. |
| Precautions |
|
Suspected coronary artery disease. Cerebrovascular accidents. Aortic aneurysm. Increased intracranial pressure. Renal disease. Treat paresthesias and/or numbness with pyridoxine. Discontinue if blood dyscrasias occur. Obtain CBC and ANA titer periodically; consider discontinuing if SLE occurs. Surgery. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
|
Caution with MAOIs. Profound hypotension with potent parenteral antihypertensives (eg, diazoxide). Antagonized by NSAIDs. May block epinephrine. |
| Adverse Reactions |
|
Headache, anorexia, GI disturbances, palpitations, edema, flushing, nasal congestion, lacrimation, rash, tachycardia, angina, orthostatic hypotension, blood dyscrasias, peripheral neuritis, SLE. |
| How Supplied |
|
Contact supplier. |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
