Monograph Details
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Cardiovascular System
> Hypertension
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DIOVAN HCT 320mg/25mg |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Angiotensin II receptor blocker + diuretic. |
| Generic Name |
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Valsartan 320mg, hydrochlorothiazide 25mg; tabs. |
| Also |
• DIOVAN HCT 160mg/12.5mg
• DIOVAN HCT 160mg/25mg
• DIOVAN HCT 320mg/12.5mg
• DIOVAN HCT 80mg/12.5mg
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Not for initial therapy. Switching from monotherapy with either component: one 80mg/12.5mg, 160mg/12.5mg, or 320mg/12.5mg tablet once daily; adjust at 3–4 week intervals; usual max 320mg/25mg per day. Or, substitute for individually-titrated components. |
| Contraindications |
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Anuria. Sulfonamide allergy. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Salt/volume depletion. Hepatic or severe renal impairment. CrCl ≤30mL/minute: not recommended. Arrhythmias. Postsympathectomy. Diabetes. Gout. Asthma. Severe CHF. Renal artery stenosis. SLE. Monitor electrolytes. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Monitor for hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Hypokalemia with corticosteroids, ACTH. Antagonized by NSAIDs. Orthostatic hypotension may be potentiated by alcohol, barbiturates, narcotics, antihypertensives. Potentiates nondepolarizing muscle relaxants. Antagonizes norepinephrine. Adjust antidiabetic, antigout medications. Avoid lithium. May increase toxicity of digitalis, lithium. May interfere with parathyroid tests. |
| Adverse Reactions |
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Dizziness, viral infection, fatigue, pharyngitis, cough, diarrhea, orthostatic hypotension, electrolyte disturbances (eg, hypokalemia, hyponatremia, hypomagnesemia), hyperuricemia, increased serum cholesterol or triglycerides, rhabdomyolysis (rare). |
| How Supplied |
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Tabs—90 |
| Additional Resources |
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• Related Prescribing Note |
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