Monograph Details
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Cardiovascular System
> Hypertension
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DIOVAN |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Angiotensin II receptor blocker. |
| Generic Name |
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Valsartan 40mg+, 80mg, 160mg, 320mg; +scored; tabs. |
| Indications |
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Hypertension. |
| Children |
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<6yrs or CrCl<30mL/min: not recommended. 6–16yrs: Initially 1.3mg/kg once daily (up to 40mg total); max 2.7mg/kg (up to 160mg) once daily. If unable to swallow tabs, or calculated dose (mg/kg) does not correspond to available tablet strengths, use suspension (see literature for susp preparation). |
| Adults |
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Monotherapy and not volume-depleted: initially 80mg or 160mg once daily; max 320mg once daily. Or, add a diuretic (more effective than increasing dose above 80mg). |
| Contraindications |
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Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Correct hypovolemia before beginning therapy (may need to reduce diuretic) or monitor closely for hypotension. Hepatic or severe renal impairment. Renal artery stenosis. Severe CHF (if renal function depends on renin-angiotensin-aldosterone system). Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Concomitant K+ supplements, K+ sparing diuretics, K+ containing salt substitutes may lead to hyperkalemia and, in heart failure patients, increased serum creatinine. Concomitant ACE inhibitor and β-blocker (see literature regarding heart failure patients). |
| Adverse Reactions |
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Viral infection, fatigue, abdominal pain, neutropenia, rhabdomyolysis (rare). |
| How Supplied |
Tabs 40mg—30
Tabs 80mg, 160mg, 320mg—90 |
| Additional Resources |
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• Related Prescribing Note |
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