Monograph Details
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Cardiovascular System
> Hypertension
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DILACOR XR |
| Manufacturer |
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Watson Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (benzothiazepine). |
| Generic Name |
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Diltiazem HCl 120mg, 180mg, 240mg; ext-rel caps. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Do not crush or chew. Take in AM on empty stomach. Initially 180mg or 240mg once daily. Usual range: 180–480mg/day; max 540mg/day. Over 60 yrs: may start with 120mg daily. |
| Contraindications |
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Sick sinus syndrome, 2nd- or 3rd-degree AV block unless paced. Hypotension. Acute MI and pulmonary congestion documented by X-ray on admission. |
| Precautions |
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Impaired ventricular, renal or hepatic function. Monitor hepatic function. Discontinue if persistent rash occurs. Preexisting severe gastric stricture. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Digoxin and β-blockers may lead to AV block. Monitor digoxin levels. Serum propranolol, carbamazepine levels may be increased. Potentiation with cimetidine, cyclosporine. Anesthetics may potentiate cardiac depression. Additive hypotensive effects with antihypertensives. |
| Adverse Reactions |
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Pharyngitis, cough, flu syndrome, edema, myalgia, GI upset, sinusitis, asthenia, vasodilatation, pain, arthrosis, insomnia, tinnitus, rash; liver abnormalities (rare). |
| How Supplied |
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Caps—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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