Monograph Details
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Cardiovascular System
> Hypertension
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COVERA-HS |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (diphenylalkylamine). |
| Generic Name |
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Verapamil HCl 180mg, 240mg; controlled-onset ext-rel tabs. |
| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Swallow whole once daily at bedtime. ≥18 years: initially 180mg; may titrate upwards in steps to 240mg, then 360mg, then 480mg if necessary. |
| Contraindications |
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Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree heart block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. |
| Precautions |
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Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. GI narrowing. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. |
| Adverse Reactions |
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Hypotension, constipation, upper respiratory infection, dizziness, fatigue, GI upset, AV block, bradycardia, paresthesia, elevated liver enzymes, paralytic ileus. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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