Monograph Details
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Cardiovascular System
> Hypertension
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CORZIDE 80/5 |
| Manufacturer |
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King Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Noncardioselective β-blocker + diuretic. |
| Generic Name |
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Nadolol 80mg, bendroflumethiazide 5mg; scored tabs. |
| Also |
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• CORZIDE 40/5
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Titrate components. Renally impaired: increase dosing interval; see literature. |
| Contraindications |
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Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy. |
| Precautions |
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Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes, renal function. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Hypotension with alcohol, CNS depressants, MAOIs, prazosin, other antihypertensives. Bradycardia with catecholamine-depleting drugs. Adjust antidiabetic, anticoagulant medication. ACTH, amphotericin B, corticosteroids increase hypokalemia risk. May increase toxicity of diazoxide, digitalis, lithium, verapamil, lidocaine. Antagonized by NSAIDs. Antagonizes methenamine, antigout drugs. May block epinephrine. May interfere with glaucoma, parathyroid screening tests. |
| Adverse Reactions |
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Cardiac failure, bronchospasm, bradycardia, heart block, fatigue, fluid and electrolyte imbalance, orthostatic hypotension, GI upset, dizziness, blurred vision, cold extremities, rash, pruritus, blood dyscrasias. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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