Monograph Details
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Cardiovascular System
> Hypertension
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CAPOZIDE 50/25 |
| Manufacturer |
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Par Pharmaceutical, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor + diuretic. |
| Generic Name |
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Captopril 50mg, hydrochlorothiazide 25mg; scored tabs. |
| Also |
• CAPOZIDE 25/15
• CAPOZIDE 25/25
• CAPOZIDE 50/15
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| Indications |
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Hypertension. |
| Children |
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See literature. |
| Adults |
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Take 1 hr before meals. As initial therapy: one 25/15 tab daily; adjust at 6 wk intervals. Previously titrated: use same doses as individual components. Usual max 150mg captopril, 50mg hydrochlorothiazide daily. |
| Contraindications |
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Anuria. Sulfonamide allergy. History of ACEI-associated angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal or hepatic dysfunction. Salt/volume depletion. CHF. Dialysis (esp. high-flux membrane). Aortic stenosis. Diabetes. Gout. Asthma. Postsympathectomy. Surgery. Monitor electrolytes. Monitor WBCs and renal function in renal and collagen vascular disease. Discontinue if neutropenia, agranulocytosis, angioedema or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Potentiated by antihypertensives. Potentiates tubocurarine. May antagonize sulfonylureas, oral anticoagulants, uricosurics. May be antagonized by NSAIDs, sympathomimetics. May increase digitalis, lithium, insulin, diazoxide toxicity. Hyperkalemia with potassium-sparing diuretics and supplements. Hypokalemia with ACTH, corticosteroids. Orthostatic hypotension may be increased by alcohol, CNS depressants. May interfere with parathyroid, urinary acetone tests. |
| Adverse Reactions |
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Neutropenia, agranulocytosis, proteinuria, nephrotic syndrome, orthostatic hypotension, fluid or electrolyte imbalance, rash, GI upset, dysgeusia, hyperglycemia, hyperuricemia, dizziness, headache, cough, pruritus, angioedema, tachycardia, chest pain, jaundice, blurred vision, angioedema. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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