Monograph Details
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Cardiovascular System
> Hypertension
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CAPOTEN |
| Manufacturer |
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Par Pharmaceutical, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Captopril 12.5mg, 25mg, 50mg, 100mg; scored tabs. |
| Indications |
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Hypertension. |
| Children |
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See literature. |
| Adults |
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Take 1 hr before meals. Initially 25mg 2–3 times daily. After 1–2 wks may increase to 50mg 2–3 times daily. If control unsatisfactory, see literature. Titrate to usual dose after several days. Monitor closely for 1st 2 wks and if dose increased; max 450mg/day. Renal impairment: see literature. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal impairment. Salt/volume depletion. CHF. Dialysis (esp. high-flux membrane). Aortic stenosis. Monitor WBCs and renal function in renal and collagen vascular disease. Monitor for hyperkalemia in diabetics and renal insufficiency. Surgery. Discontinue if neutropenia, agranulocytosis, angioedema, or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Caution with K+-sparing diuretics and K+-containing supplements. May be antagonized by NSAIDs. Potentiated by diuretics, β-blockers, adrenergic antagonists. May increase lithium levels. May produce false (+) urinary acetone. |
| Adverse Reactions |
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Headache, dysgeusia, rash, pruritus, dizziness, fatigue, cough, proteinuria, nephritis, GI upset, hyperkalemia, hyponatremia, back pain, tachycardia, dry mouth, jaundice, somnolence, sweating, sinusitis, impotence, angioedema. |
| How Supplied |
Tabs 25mg, 50mg—100, 1000
12.5mg, 100mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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