Monograph Details
|
|
Cardiovascular System
> Hypertension
|
|
CALAN |
| Manufacturer |
|
Pfizer Labs |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Calcium channel blocker (diphenylalkylamine). |
| Generic Name |
|
Verapamil HCl 40mg, 80mg+, 120mg+; tabs; +scored. |
| Also |
|
• CALAN SR
|
| Indications |
|
Hypertension. |
| Children |
|
<18yrs: not recommended. |
| Adults |
|
Initially 80mg 3 times daily; usual max 360mg/day in divided doses. Elderly or small patients: initially 40mg 3 times daily. |
| Contraindications |
|
Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. |
| Precautions |
|
Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
|
Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, phenobarbital), rifampin. Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. |
| Adverse Reactions |
|
Constipation, dizziness, nausea, hypotension, headache, edema, CHF, fatigue, dyspnea, bradycardia, AV block, rash, flushing, elevated hepatic enzymes, paralytic ileus. |
| How Supplied |
Calan 40mg—100
80mg—100, 500, 1000
120mg—100, 1000
SR 120mg, 180mg—100
SR 240mg—100, 500 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
