Monograph Details
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Cardiovascular System
> Hypertension
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BYSTOLIC |
| Manufacturer |
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Forest Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cardioselective β-blocker. |
| Generic Name |
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Nebivolol (as HCl) 2.5mg, 5mg, 10mg; tabs. |
| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18yrs: initially 5mg once daily. Individualize; may increase at 2-week intervals; max 40mg/day. Severe renal or moderate hepatic impairment: initially 2.5mg once daily. |
| Contraindications |
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Severe hepatic impairment (Child-Pugh >B). Severe bradycardia. 2nd- or 3rd degree AV block. Cardiogenic shock. Overt heart failure. Sick sinus syndrome (unless paced). |
| Precautions |
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CHF. Angina. Recent MI. Bronchospastic disease. Diabetes. Hyperthyroidism. Severe renal impairment. Moderate hepatic impairment. Avoid abrupt cessation (taper over 1–2 weeks). Surgery. Peripheral vascular disease. Pheochromocytoma. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Caution with phenylalkylamine and benzothiazepine calcium channel blockers (eg, verapamil, diltiazem), antiarrhythmics (eg disopyramide), digoxin, reserpine, guanethidine; monitor. May be potentiated by CYP2D6 inhibitors (eg, quinidine, propafenone, paroxetine, fluoxetine); may need to reduce dose. If on both nebivolol and clonidine, discontinue nebivolol before tapering clonidine. May block epinephrine. |
| Adverse Reactions |
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Headache, fatigue, dizziness, GI upset. |
| How Supplied |
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Tabs—30, 100 |
| Additional Resources |
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• Related Prescribing Note |
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