Monograph Details
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Cardiovascular System
> Hypertension
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ATACAND |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Angiotensin II receptor blocker. |
| Generic Name |
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Candesartan cilexetil 4mg, 8mg, 16mg, 32mg; tabs. |
| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18yrs: Monotherapy and not volume-depleted: initially 16mg once daily; usual range: 8–32mg per day once daily or in 2 divided doses. Salt/volume depleted or moderate hepatic impairment: consider lower initial dose. May add diuretic if needed. |
| Contraindications |
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Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Correct hypovolemia before starting or monitor closely. Severe renal impairment. Severe CHF. Renal artery stenosis. Elderly. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Monitor lithium and for hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. |
| Adverse Reactions |
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Back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis, rhabdomyolysis (rare). |
| How Supplied |
Tabs 4mg, 8mg—30
16mg, 32mg—30, 90 |
| Additional Resources |
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• Related Prescribing Note |
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