Monograph Details
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Cardiovascular System
> Hypertension
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ADALAT CC |
| Manufacturer |
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Bayer Corp, Pharmaceutical Div. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (dihydropyridine). |
| Generic Name |
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Nifedipine 30mg, 60mg, 90mg; ext rel tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Swallow whole on empty stomach. Initially 30mg once daily. Usual maintenance: 30–60mg once daily. Titrate over 7–14 days; max 90mg/day. |
| Precautions |
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Aortic stenosis. Angina. Severe obstructive coronary artery disease. Heart failure. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates antihypertensives, digoxin, tacrolimus. Angina and heart failure possible with β-blockers. Potentiated by cimetidine, doxazosin, ketoconazole, valproic acid, grapefruit juice, other CYP3A4 inhibitors. Antagonized by rifampin, phenytoin, carbamazepine, St. John's wort, other CYP3A4 inducers. Monitor oral anticoagulants, quinidine. Hypotension possible with fentanyl. |
| Adverse Reactions |
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Peripheral edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps, rash; exacerbation of angina, heart failure (rare). |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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