Monograph Details
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Cardiovascular System
> Hypertension
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ACEON |
| Manufacturer |
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Solvay Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Perindopril erbumine 2mg, 4mg, 8mg; scored tabs. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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If not on diuretic: initially 4mg once daily or in 2 divided doses. Titrate; max 16mg/day. Usual maintenance 4–8mg once daily. If on diuretic: suspend diuretic, if possible, 2–3 days before starting therapy. If diuretic cannot be discontinued (monitor closely): initially 2–4mg once daily or in 2 divided doses; max 16mg/day. Renal impairment: CrCl <30mL/min: not recommended; CrCl >30mL/min: initially 2mg/day: max 8mg/day. |
| Elderly |
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>65 yrs: usual max 8mg/day. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal or hepatic impairment. Salt/volume depletion. Severe CHF. Renal artery or aortic stenosis. Monitor for neutropenia in renal or collagen vascular disease. Monitor for hyperkalemia in diabetics. Dialysis. Surgery. Discontinue if laryngeal edema, angioedema, marked elevations of liver enzymes or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Pregnancy (Cat.C in 1st trimester). Nursing mothers. |
| Interactions |
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Excessive hypotension with diuretics. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes, others (e.g., cyclosporine, indomethacin, heparin). May increase lithium levels. Caution with gentamicin, digoxin. |
| Adverse Reactions |
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Headache, cough, dizziness, sinusitis, viral infection, hypertonia, upper extremity pain, dyspepsia, fever, proteinuria, palpitations. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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