Monograph Details
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Cardiovascular System
> Hypertension
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ACCURETIC 10/12.5 |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor + diuretic. |
| Generic Name |
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Quinapril (as HCl) 10mg, hydrochlorothiazide 12.5mg; scored tabs. |
| Also |
• ACCURETIC 20/12.5
• ACCURETIC 20/25
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Not for initial therapy. Previously titrated: use same doses as individual components. Switching from quinapril monotherapy: initially one Accuretic 10/12.5 tab or one Accuretic 20/12.5 tab once daily; allow 2–3 weeks before increasing hydrochlorothiazide component. Switching from hydrochlorothiazide 25mg/day monotherapy: initially one Accuretic 10/12.5 tab daily or one Accuretic 20/12.5 tab once daily. Adjust based on response and serum potassium. Renal impairment (CrCl ≤30mL/min): not recommended. |
| Contraindications |
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Anuria. Sulfonamide allergy. History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Salt/volume depletion. Renal or hepatic impairment. Ischemic heart disease. Diabetes. Dialysis (esp. high-flux membrane). Postsympathectomy. Surgery. SLE. History of angioedema. Severe CHF. Cerebrovascular disease. Gout. Black patients may have a higher risk of angioedema than non-blacks. Monitor: electrolytes, renal function in severe CHF and renal artery stenosis, WBCs in collagen vascular disease and/or renal disease. Discontinue if jaundice, marked elevations in liver enzymes, or angioedema or laryngeal edema occurs. Elderly. Pregnancy (Cat.C in 1st trimester). Nursing mothers: not recommended. |
| Interactions |
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Orthostatic hypotension potentiated by alcohol, CNS depressants. Hyperkalemia with K+ supplements, K+ containing salt substitutes, K+ sparing diuretics. Hypokalemia more likely with corticosteroids, ACTH. Reduces tetracycline absorption (Accuretic contains magnesium). May increase lithium levels. Antagonized by NSAIDs. Potentiates nondepolarizing muscle relaxants. Monitor antidiabetic agents. May interfere with parathyroid tests. May antagonize pressor amines. |
| Adverse Reactions |
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Cough, headache, somnolence, orthostatic hypotension, electrolyte disturbances. |
| How Supplied |
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Tabs—90 |
| Additional Resources |
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• Related Prescribing Note |
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