Monograph Details
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Cardiovascular System
> Hypertension
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ACCUPRIL |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Quinapril (as HCl) 5mg+, 10mg, 20mg, 40mg; tabs; +scored. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Monotherapy: initially 10–20mg once daily. Usual maintenance: 20–80mg daily in 1–2 divided doses. Elderly: initially 10mg once daily. Patients on diuretic: suspend diuretic for 2–3 days before starting; resume diuretic if BP not controlled by quinapril alone. If diuretic cannot be discontinued, or if creatinine clearance (CrCl) 30–60mL/min: initially 5mg daily. CrCl 10–30mL/min: initially 2.5mg daily. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Salt/volume depletion. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Monitor renal function in severe CHF, hypertension, or renal artery stenosis. Monitor WBCs in renal or collagen vascular disease. Monitor for hyperkalemia in diabetics. Surgery. Discontinue if angioedema or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers. |
| Interactions |
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K+ supplements, K+ sparing diuretics, K+ containing salt substitutes may cause hyperkalemia. May increase lithium levels. Antagonizes tetracycline. Potentiated by diuretics. |
| Adverse Reactions |
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Headache, dizziness, fatigue, cough, GI upset, hyperkalemia, back pain, tachycardia, dry mouth, somnolence, sweating, sinusitis. |
| How Supplied |
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Tabs—90 |
| Additional Resources |
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• Related Prescribing Note |
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