Monograph Details
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Cardiovascular System
> Hyperlipoproteinemias
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ZETIA |
| Manufacturer |
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Merck/Schering-Plough |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cholesterol absorption inhibitor. |
| Generic Name |
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Ezetimibe 10mg; tabs. |
| Indications |
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Adjunct to diet, alone or in combination with an HMG-CoA reductase inhibitor (statin), in primary hypercholesterolemia (heterozygous familial and non-familial) to reduce elevated total-C, LDL-C, and Apo B. Adjunct to diet and in combination with fenofibrate to reduce elevated total-C, LDL-C, Apo B, and non-HDL-C in mixed hyperlipidemia. Adjunct to other lipid-lowering treatments, or if these treatments are unavailable, with atorvastatin or simvastatin to reduce elevated total-C and LDL-C in homozygous familial hypercholesterolemia. Adjunct to diet in homozygous familial sitosterolemia to reduce elevated sitosterol and campesterol. |
| Children |
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<10 years: not recommended. |
| Adults |
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≥10 years: 10mg once daily. |
| Contraindications |
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The use of ezetimibe with a statin is contraindicated in active liver disease or unexplained persistent elevations in serum transaminases. Statins are contraindicated in pregnancy and nursing. |
| Precautions |
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Moderate to severe hepatic insufficiency: not recommended. If given with a statin: monitor liver function initially and then as recommended for the statin. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Concomitant fibrates (except fenofibrate): not recommended. Potentiates cyclosporine. Potentiated by fenofibrate, gemfibrozil, cyclosporine. Monitor warfarin, cyclosporine. Separate dosing of bile acid sequestrants (give ≥2 hours before or ≥4 hours after). |
| Adverse Reactions |
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Back pain, arthralgia, diarrhea, abdominal pain, fatigue, cough; rare: myopathy/rhabdomyolysis; w. statin: increased serum transaminases. |
| Extra Text |
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Note: For more information on statins, see their entries. |
| How Supplied |
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Tabs—30, 90, 500 |
| Additional Resources |
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• Related Prescribing Note |
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