Monograph Details
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Cardiovascular System
> Hyperlipoproteinemias
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WELCHOL |
| Manufacturer |
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Daiichi-Sankyo |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Bile acid sequestrant. |
| Generic Name |
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Colesevelam HCl 625mg; tabs. |
| Indications |
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Adjunct to diet and exercise to reduce elevated LDL-C in primary hypercholesterolemia (Type IIa), alone or with a statin, when response to nondrug therapy is inadequate. |
| Children |
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Not recommended. |
| Adults |
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Take with a meal and liquid. 3 tabs twice daily or 6 tabs once daily. With a statin: may be dosed at same time or dosed apart. |
| Contraindications |
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Bowel obstruction. Serum TG>500mg/dL. History of hypertriglyceridemia-induced pancreatitis. |
| Precautions |
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TG levels >300mg/dL. Susceptibility to Vit. A, D, E, or K deficiencies. GI motility disorders (eg, dysphagia). Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Monitor drugs with a narrow therapeutic index, glyburide, levothyroxine, oral contraceptives containing ethinyl estradiol and norethindrone, phenytoin, warfarin; give at least 4 hours prior to colesevelam. |
| Adverse Reactions |
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Constipation, dyspepsia, abdominal pain, nausea. |
| How Supplied |
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Tabs—180 |
| Additional Resources |
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• Related Prescribing Note |
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