Monograph Details
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Cardiovascular System
> Edema
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ZAROXOLYN |
| Manufacturer |
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UCB Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Quinazoline. |
| Generic Name |
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Metolazone 2.5mg, 5mg, 10mg; tabs. |
| Indications |
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Edema. |
| Children |
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Not recommended. |
| Adults |
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5–20mg once daily. |
| Contraindications |
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Do not interchange brands. Anuria. Hepatic coma or precoma. Sulfonamide allergy. |
| Precautions |
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For switching with Mykrox see literature. Renal or hepatic dysfunction. Azotemia. Arrhythmias. Diabetes. Gout. SLE. Monitor fluids, electrolyes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. Antagonizes antidiabetic, antigout medications, methenamine. Monitor anticoagulants. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. Antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, CNS depressants, other antihypertensives. |
| Adverse Reactions |
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Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, blood dyscrasias, chest or joint pain, cutaneous vasculitis. |
| How Supplied |
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Tabs—100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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