Monograph Details
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Cardiovascular System
> Edema
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Hydrochlorothiazide |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Thiazide. |
| Generic Name |
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Hydrochlorothiazide 25mg, 50mg; scored tabs. |
| Indications |
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Edema. |
| Children |
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See literature. 1–2mg/kg per day in 1 or 2 divided doses. <6months: up to 3mg/kg per day in 2 divided doses. ≤2years: max 37.5mg/day. 2–12years: up to 100mg/day. |
| Adults |
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25–100mg daily in single or divided doses; may give on intermittent schedule (every other day or 3–5 days/wk). |
| Contraindications |
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Anuria. Sulfonamide allergy. |
| Precautions |
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Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). K+ supplements or K+ sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Hyperglycemia, hyperuricemia more likely with diazoxide. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests. |
| Adverse Reactions |
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Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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