Monograph Details
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Cardiovascular System
> Edema
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DYRENIUM |
| Manufacturer |
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WellSpring Pharmaceuticals, Corp. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Diuretic (K+ sparing). |
| Generic Name |
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Triamterene 50mg, 100mg; caps. |
| Indications |
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Edema. |
| Children |
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Not recommended. |
| Adults |
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Take after meals. Initially 100mg twice daily; max 300mg daily. |
| Contraindications |
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Concomitant K+ supplements, K+-sparing diuretics, salt substitutes. Hyperkalemia. Anuria. Renal impairment. Severe hepatic disease. |
| Precautions |
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Diabetes. Severely ill. Acidosis predisposition. Electrolyte imbalance. History of renal stones. Gout. Hepatic impairment. Monitor blood, electrolytes, hepatic and renal function frequently. Discontinue if serum potassium >5.5mEq/L or renal values progress. ECG changes or arrhythmias require prompt treatment. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid K+-sparing diuretics, K+ supplements, and K+ containing salt substitutes. Lithium toxicity. Hyperkalemia more likely with ACE inhibitors. Hyponatremia with sulfonylureas. Acute renal failure with NSAIDs. Adjust antidiabetic medications. Potentiates antihypertensives, nondepolarizing muscle relaxants, anesthetics. |
| Adverse Reactions |
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Rarely: anaphylaxis, rash, photosensitivity, hyper- or hypokalemia, azotemia, renal stones, acute interstitial nephritis, jaundice, GI upset, electrolyte disturbances, blood dyscrasias, weakness, fatigue, dizziness, dry mouth. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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