Monograph Details
|
|
Cardiovascular System
> Edema
|
|
DIURIL INJ |
| Manufacturer |
|
Ovation Pharmaceuticals, Inc. |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Diuretic (thiazide). |
| Generic Name |
|
Chlorothiazide (as sodium) 500mg/vial; pwd for IV inj after reconstitution; contains mannitol. |
| Indications |
|
Edema. |
| Children |
|
Not recommended. |
| Adults |
|
0.5–1g IV once or twice daily. |
| Contraindications |
|
Anuria. Sulfonamide allergy. |
| Precautions |
|
Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+ -sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
|
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests. |
| Adverse Reactions |
|
Electrolyte disorders (especially hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values. |
| How Supplied |
|
Vial—1 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
