Monograph Details
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Cardiovascular System
> Edema
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DEMADEX |
| Manufacturer |
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Roche Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Diuretic (loop). |
| Generic Name |
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Torsemide 5mg, 10mg, 20mg, 100mg; scored tabs. |
| Also |
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• DEMADEX INJECTION
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| Indications |
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Edema. |
| Children |
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Not recommended. |
| Adults |
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Give IV dose over a period of 2 minutes. Edema due to CHF: 10–20mg once daily oral or IV, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to renal disease: 20mg once daily oral or IV, if needed titrate upwards by doubling dose until desired response; max 200mg daily. Edema due to hepatic disease: 5–10mg once daily oral or IV, give with aldosterone antagonist or potassium-sparing diuretic, may titrate upwards by doubling dose until desired response is achieved; max 40mg daily. |
| Contraindications |
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Anuria. Sulfonamide allergy. |
| Precautions |
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Hepatic disease with cirrhosis and ascites. Monitor electrolytes, BUN, creatinine, uric acid, and fluids. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Lithium and salicylate toxicity. Caution with NSAIDs. Antagonized by probenecid and indomethacin. Give oral dose 2 hours before or 4 hours after cholestyramine. Ototoxicity with aminoglycosides and ethacrynic acid. |
| Adverse Reactions |
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Dizziness, headache, nausea, weakness, vomiting, hyperglycemia, hyperuricemia, hypokalemia, excessive thirst, hypovolemia, impotence, esophageal hemorrhage, dyspepsia. |
| How Supplied |
Tabs—100
Ampules—2mL, 5mL |
| Additional Resources |
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• Related Prescribing Note |
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