Monograph Details
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Cardiovascular System
> Edema
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Chlorothiazide |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Thiazide. |
| Generic Name |
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Chlorothiazide 250mg, 500mg; scored tabs. |
| Indications |
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Edema. |
| Children |
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<6 months: up to 15mg/lb per day in 2 divided doses. ≥6 months: 10mg/lb per day in 2 divided doses. |
| Adults |
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Initially 0.5g–1g once or twice daily, every other day, or 3–5 days/wk. |
| Contraindications |
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Anuria. Sulfonamide allergy. |
| Precautions |
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Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests. |
| Adverse Reactions |
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Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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