Monograph Details
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Cardiovascular System
> Edema
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BUMEX |
| Manufacturer |
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Roche Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Diuretic (loop). |
| Generic Name |
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Bumetanide 1mg; scored tabs. |
| Indications |
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Edema. |
| Children |
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<18yrs: not recommended. |
| Adults |
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0.5mg–2mg daily; max 10mg daily. Intermittent dosing optimal. |
| Contraindications |
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Anuria. Hepatic coma. Severe electrolyte depletion. |
| Precautions |
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Hepatic cirrhosis. Ascites. Sulfonamide allergy. Progressive renal disease. Gout. Diabetes. Postsympathectomy. Monitor electrolytes, blood, liver function. Potassium supplementation may be needed. Potassium-losing nephropathy. Aldosterone excess. Discontinue if renal dysfunction progresses. Ventricular arrhythmias. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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May increase digitalis, lithium toxicity. Hypokalemia with digitalis, diuretics in CHF. Alcohol, CNS depressants may increase orthostatic hypotension. Avoid probenecid, indomethacin. Ototoxicity may be potentiated with aminoglycosides. |
| Adverse Reactions |
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Muscle cramps, dizziness, hypotension, headache, nausea, encephalopathy, ototoxicity, rash, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, blood dyscrasias. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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