Monograph Details
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Cardiovascular System
> Edema
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Bumetanide Inj |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Diuretic (loop). |
| Generic Name |
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Bumetanide 0.25mg/mL; contains benzyl alcohol. |
| Indications |
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Edema. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Initially 0.5–1mg IM or IV. May give 1–2 more doses at 2–3 hour intervals; max 10mg/day. |
| Contraindications |
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Anuria. Infants. Hepatic coma. Severe electrolyte depletion. |
| Precautions |
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Hepatic cirrhosis. Ascites. Progressive renal disease. Gout. Diabetes. Postsympathectomy. Monitor electrolytes, blood, liver function. May need K+ supplementation. K+ losing nephropathy. Discontinue if renal dysfunction progresses. Aldosterone excess. Ventricular arrhythmias. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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May increase digitalis, lithium toxicity. Hypokalemia with digitalis, diuretics in CHF. Alcohol, CNS depressants increase orthostatic hypotension. Avoid probenecid, indomethacin. Ototoxicity may be potentiated with aminoglycosides. |
| Adverse Reactions |
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Muscle cramps, dizziness, hypotension, headache, nausea, encephalopathy, ototoxicity, rash, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, blood dyscrasias. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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