Monograph Details
|
|
Cardiovascular System
> Edema
|
|
Amiloride/HCTZ |
| Manufacturer |
|
Various generic manufacturers |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
K+-sparing + thiazide. |
| Generic Name |
|
Amiloride HCl 5mg, hydrochlorothiazide 50mg; scored tabs. |
| Indications |
|
Edema when normokalemia is important. |
| Children |
|
Not recommended. |
| Adults |
|
Initially 1 tab daily with food; may increase to 2 tabs daily in single or divided doses. After initial diuresis, reassess therapy; may be given intermittently for maintenance. |
| Contraindications |
|
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy. |
| Precautions |
|
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
|
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test. |
| Adverse Reactions |
|
Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values. |
| How Supplied |
|
Contact supplier. |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
