Monograph Details
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Cardiovascular System
> Edema
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Amiloride |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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K+-sparing. |
| Generic Name |
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Amiloride HCl 5mg; tabs. |
| Indications |
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Adjunct in edema where normokalemia is important. |
| Children |
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Not recommended. |
| Adults |
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Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring. After initial diuresis, reassess therapy; may be given intermittently for maintenance. |
| Contraindications |
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Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy. |
| Precautions |
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Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test. |
| Adverse Reactions |
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Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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