Monograph Details
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Cardiovascular System
> Edema
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ALDACTONE |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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K+-sparing. |
| Generic Name |
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Spironolactone 25mg, 50mg+, 100mg+; tabs; +scored. |
| Indications |
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Edema. |
| Children |
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Initially 3.3mg/kg per day in single or divided doses. |
| Adults |
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Initially 25–200mg daily. Usual starting dosage: 100mg/day in single or divided doses. Maintain for 5 days, then retitrate. |
| Contraindications |
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Hyperkalemia. Renal impairment. |
| Precautions |
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Hepatic cirrhosis. Hyponatremia. Surgery. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended. |
| Interactions |
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Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with corticosteroids, ACTH. Antagonized by NSAIDs. Potentiates ganglionic blockers, alcohol, barbiturates, narcotics, skeletal muscle relaxants. Digitalis toxicity. |
| Adverse Reactions |
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Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis. |
| How Supplied |
Tabs 25mg—100, 500, 2500
50mg, 100mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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