Monograph Details
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Cardiovascular System
> Edema
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ALDACTAZIDE 25 |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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K+-sparing + thiazide. |
| Generic Name |
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Spironolactone 25mg, hydrochlorothiazide 25mg; tabs. |
| Also |
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• ALDACTAZIDE 50
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| Indications |
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Edema. |
| Children |
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Not for initial therapy. Usual maintenance: 1.65–3.3mg spironolactone per kg daily. |
| Adults |
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Not for initial therapy. Usual maintenance: 4 tabs daily in single or divided doses. |
| Contraindications |
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Hyperkalemia. Anuria. Renal impairment. Sulfonamide allergy. Severe hepatic impairment. |
| Precautions |
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Hepatic cirrhosis. Hyponatremia. Surgery. Gout. Diabetes. SLE. Postsympathectomy. Monitor electrolytes. Pregnancy. Nursing mothers: not recommended. |
| Interactions |
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Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants. May need to adjust insulin or oral hypoglycemic dosage. Antagonized by NSAIDs. Digitalis toxicity. May interfere with parathyroid tests. |
| Adverse Reactions |
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Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis. Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values. |
| How Supplied |
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Tabs—100, 2500 |
| Additional Resources |
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• Related Prescribing Note |
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