Monograph Details
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Cardiovascular System
> Edema
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ACETAZOLAMIDE INJECTION |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Carbonic anhydrase inhibitor. |
| Generic Name |
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Acetazolamide 500mg/vial; pwd for inj after reconstitution; preservative-free. |
| Indications |
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Edema. |
| Children |
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Not recommended. |
| Adults |
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Give by IV inj. Edema: give 1–2 days on, 1 day off. 250mg–375mg once daily. CHF: 250–375mg once daily in the AM. Acute high altitude sickness: see literature. |
| Contraindications |
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Hypokalemia. Hyponatremia. Severe renal, hepatic, or adrenocortical impairment. Hyperchloremic acidosis. Cirrhosis. Chronic noncongestive angle-closure glaucoma. Sulfonamide allergy. |
| Precautions |
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Respiratory impairment. Renal calcium calculi. Diabetes. Gout. Monitor blood and electrolytes. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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inhibits renal excretion of basic drugs and promotes excretion of acidic drugs. May increase toxicity of salicylates (acidosis), folic acid antagonists. Hypokalemia with corticosteroids, potassium wasting diuretics. Monitor phenytoin, primidone, antihyperglycemics, quinidine, lithium, cyclosporine. Antagonizes methenamine. |
| Adverse Reactions |
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Anorexia, drowsiness, confusion, malaise, depression, GI distress, paresthesias, tinnitus, acidosis, initial hypokalemia, hyperuricemia, transient myopia; renal calculi, nephrotoxicity, hepatic dysfunction, blood dyscrasias, rash, fever, photosensitivity (rare). |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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